Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy

Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy

Authors

  • Muhammad Khalid Ch
  • Muhammad Saqib Saeed
  • Rizwan Iqbal
  • Akhtar Ali

DOI:

https://doi.org/10.21649/akemu.v22i1.803

Keywords:

Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.

Abstract

Abstract

Background:  Tuberculous pleurisy is a common extrapulmonary manifestation and is second to tuberculous lymphadenitis. Due to its paucibacillary in origin, its diagnosis is a challenge. Furthermore, it is also complicated by the emergence of MDR. Gene Xpert MTB/RIF is a new rapid promising innovation for the detection of mycobacterium tuberculosis and its resistance to Rifampicin, giving result within two hours.

Objective:  To evaluate the diagnostic role of Gene Xpert MTB/RIF in suspected cases of tuberculous pleurisy.

Study Design:  Cross sectional study.

Study Setting:  Institute of Chest Medicine Mayo Hospital – a Tertiary Care Hospital affiliated with King Edward Medical University, Lahore.

Methodology:  The study group, one hundred (M-60 and F-40) cases having exudative, predominantly lymphocytic pleural effusion with strong suspicion of tuberculous in origin were enrolled randomly for Gene Xpert MTB / RIF.

Results:  Among one hundred study cases, Gene Xpert detected mycobacterium tuberculosis in 12(12%) cases [M-8 (13.3%) and F-4 (10%)]. Resistance to Rifampacin was detected in 6 (6%) cases [M-2 (3.3%) and F-4 (10%)].

Conclusion:  Gene Xpert MTB/RIF is a useful new rapid promising technique to diagnose tuberculous pleurisy. Although at present it has limited availability and utility.

Key Words:  Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.

Downloads

Published

02/13/2016

How to Cite

Ch, M. K., Saeed, M. S., Iqbal, R., & Ali, A. (2016). Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy. Annals of King Edward Medical University, 22(1), 78. https://doi.org/10.21649/akemu.v22i1.803

Issue

Section

Medicine & Allied

Most read articles by the same author(s)

Loading...