Role of Concomitant Chemo radiotherapy in Advanced Head & Neck Cancer.
Keywords:Concomitant chemo-radio therapy, head and neck.
AbstractA prospective study was conducted at Clinical Oncology Department K.E Medical College/Mayo Hospital, Lahore from March, 2003 to February 2004 to evaluate the response in 25 eligible advanced irresectable head and neck cancer patients treated with concomitant chemo-radiotherapy. Male patients were 18(72%) in number and female were 7(28%). T2 lesions were treated with a total dose of 6500 cGy while T3 and T4 lesions were given a dose of 6500 - 7500 cGy in conventional fractions. Single agent, cisplatin (100 mg/m2) was given with radiation therapy. Thirteen (52%) patients had a complete response and 9 (36%) patients had partial response. Concomitant chemo-radiation therapy is a better option for irresectable stage III and IV head and neck cancers with manageable toxicities (Grade III and IV) in majority of the patients.
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