Clinical Spectrum of Early Onset Neonatal Sepsis

  • Muhammad Khalid Masood
  • Naeem Butt
  • Saadia Sharif
  • Yaqoob Kazi


Objective:  To describe clinical spectrum of early onset neonatal sepsis in our set up. Materials and Methods:  This study was conducted at Neonatology Unit, Department of Pediatric Medi-cine, Services Hospital, Lahore from 01-07-2007 to 31-12-07. Subjects and Methods:  The data of all the admitted neonates with culture proven early onset neonatal sep-sis were analyzed for age, weight, gender, and clinical presentations at the time of admission. Results:  The mean age of neonates at time of presen-tation was 2.26 ± 1.661 days. Fifty seven percent were boys with male to female ratio 1.32 : 1.The mean weight at time of presentation was 2.9 kilograms, maximum with the standard deviation of 0.319. Ref-usal to feed was the most common 68%, followed by respiratory distress 47%, and lethargy 41%. Other symptoms included fits 20%, vomiting 18%, irrit-ability 16%, diarrhea 14%, jaundice 8%, bleeding 8% and fever in 7% of patients. Temperature instability (51%) was the most common clinical sign followed by poor sucking 48%, shock 25%, tachycardia 16%, cya- nosis 12%, bradycardia 9%, petechiae and purpura 12%, grunting 5%, apnea 5%, and abdominal disten-sion in 2% of patients. Conclusion:  Early onset neonatal sepsis has non specific signs and symptoms so high index of suspi-cion should be kept in mind while managing a sick neonate so that early and prompt treatment can be instituted.