Frequency of Cervical Pre-Malignancy in Pregnant Women

  • Imrana Rasheed
  • Khadija Waheed
  • Sara Ejaz
  • Javeria Mushtaq
Keywords: Cervical intraepithelial neoplasia, Pap smear, HPV.


AbstractThe abnormal growth of precancerous cells on the surface of the cervix is cervical intraepithelial neo-plasia (CIN). Cervical intraepithelial neoplasia is classified according to extent of the abnormal cell growth and is classified as low grade and high grade. Human papilloma virus, a sexually transmitted virus is commonly associated with CIN. A regular Pap smear test can detect CIN at early stages and this helps in treating disease at early stage and protection against human papilloma virus can be provided with vaccine.Objective:  To find the frequency of cervical pre-malignancy in pregnant women.Patients and Methods:  This cross – sectional study was conducted at Department of Obstetrics and Gyna-ecology, Lahore. A total of 260 patients were included in this study. Pap smear samples were collected and fixed in 95% alcohol solution. Smears were sent with a histopathology form for reporting.Results:  Mean age of the patients was 27.32 ± 5.12 years. Mean gestational age was 29.60 ± 6.36 weeks. Cervical pre-malignancy on pap smear was observed in 8 patients (3.01%). All of them were CIN – I. Stratification with regard to history of smoking, history of oral contraception, low socioeconomic status, multiple marriages and early marriage was done.Conclusion:  Women having history of low socio-economic status and oral contraceptive were more prevalent in developing CIN. It is recommended that cervical cancer screening by pap smear is for all women who are sexually active.  
Basic & Biomedical

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