Histopathological Grading and Staging of Invasive Ductal Carcinoma in Modified Radical Mastectomy Specimens

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Histopathological Grading and Staging of Invasive Ductal Carcinoma in Modified Radical Mastectomy Specimens

Authors

  • Quratul Ain Javaid
  • Farrukh Kamal
  • Munazza Iqbal
  • Rahat Sarfaraz
  • Asmaa Qureshy
  • Rabia Basharat

DOI:

https://doi.org/10.21649/akemu.v28i1.5004

Keywords:

Invasive ductal carcinoma, Modified radical mastectomy, Histological grade, Histopathological stage.

Abstract

Background: Breast carcinoma is the most common malignancy in females associated with high mortality rate. Objective: The purpose of present study was to describe the histological grade and histopathological stage of invasive ductal carcinoma of breast among female patients and to determine the association of tumor size and histological grade with nodal metastasis. Methods: This is an analytical cross sectional study, conducted in the department of Pathology Fatima Jinnah Medical University Lahore, Pakistan from September,2019 till February, 2020. Female patients of all age groups who were diagnosed with invasive ductal carcinoma and underwent modified radical mastectomy were included in the study. Tissue processed and Hematoxylin and Eosin staining was performed. All the sections were examined under the light microscope by myself and two other consultant pathologists independently. Histological grading of invasive ductal carcinoma was done by following Modified Scarff Bloom Richardson grading system and histopathological staging was done according to CAP protocols. Results: Total of 60 female patients diagnosed with invasive ductal carcinoma were included in the present study. Mean age of the patient calculated was 48.17± 13.12 years with age range from 26 to 90 years. Size of the tumor ranged from 1cm to 10cm. On microscopy, histological grade III was the most frequent grade (36, 60%). Out of total 60 cases n=43(71.6%) were diagnosed with regional lymph node metastasis and T2N1Mx( 17,38.3%) was the most frequent stage of the tumor. Statistically no significant association of tumor size and histological grade was observed with regional lymph node metastasis (p >0.05). Conclusion: Most of the cases of invasive ductal carcinoma in this study were diagnosed with high histological grade (Grade III) and presented with regional lymph node metastasis. Most frequent tumor stage observed was pT2N1Mx.Statistically no significant association of tumor size and histological grade was observed with lymph node metastasis.

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Published

04/27/2022

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How to Cite

Javaid, Q. A. ., Kamal, F. ., Iqbal, M. ., Sarfaraz, R. ., Qureshy, A. ., & Basharat, R. . (2022). Histopathological Grading and Staging of Invasive Ductal Carcinoma in Modified Radical Mastectomy Specimens. Annals of King Edward Medical University, 28(1). https://doi.org/10.21649/akemu.v28i1.5004

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