Relationship between Lipid Profile Changes and Severity of Liver Cirrhosis in Patients with Hepatitis C
Keywords:Liver disease, lipid profile, Child Pugh score.
AbstractObjective: To compare the lipid profile in Hepatitis C patients having cirrhosis with healthy comparison group and determine the relationship of lipid profile change with the severity of liver disease. Methods: A comparative cross sectional-study was carried out at gastroenterology OPD Unit 1 LGH, Lahore from Jan 2020 to September 2020 after approval from ethical review board of PGMI/ LGH, using non-probability purposive sampling technique. Total 113 patients diagnosed with liver cirrhosis due to hepatitis C on abdominal ultrasound and 113 healthy individuals (comparison group) of either gender with age more than 18 year were enrolled. Severity of the liver disease was assessed using Child Pugh classification. After informed consent and physical examination, data was recorded and blood sample was taken for analysis of fasting lipid profile which include total cholesterol, serum high density lipid (HDL), serum low density lipid (LDL) and serum triglycerides (TG). SPSS 23 was utilized for data analysis. Mean ± Standard deviation was used to present quantitative data and frequency (percentage) was used for qualitative data. Independent t test and ANOVA was applied for statistical analysis. Results: Mean total cholesterol in cirrhotic group and control group was 145.57+17.21 mg/dl and 161.52+16.43 mg/dl respectively and the difference was statistically significant (p value <0.001). Mean LDL and HDL in cirrhotic group was 80.49+15.37 mg/dl and 39.74+3.54 mg/dl respectively. Levels of serum HDL, VLDL, LDL, and total cholesterol were reduced significantly with liver disease progression (Child A–C). Conclusion: The reduced lipid profiles in patients with cirrhosis due to HCV infection as compared to healthy participants were significantly associated with the Child Pugh scoring. The value of lipid profile parameters decrease as the severity of liver cirrhosis increases from Child class A to Child class C.
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