Comparison of the Response of Oxytocin Versus Prostaglandin E2 Vaginal Pessary for Labour Induction in Prelabour Rupture of Membranes

Comparison of the Response of Oxytocin Versus Prostaglandin E2 Vaginal Pessary for Labour Induction in Prelabour Rupture of Membranes

Authors

  • Nazia Amjad
  • Farhat Rasheed
  • Tayyaba Imran

DOI:

https://doi.org/10.21649/akemu.v15i2.36

Abstract

Objective:  To compare the response of oxytocin versus prostaglandin E2 vaginal pessary for labour induction in prelabour rupture of membranes at term in primigravida patients with poor Bishop score.

Design:  It was a prospective comparative study.

Setting:  The study was conducted in the department of Gynae & Obs, Ittefaq hospital (Trust), Lahore during a period of one year i.e from July 2007 to June 2008.

Patients and Methods:  Fifty primigravidae with prelabour rupture of membranes at term having Bishop score < 5 or 5 were randomized into 2 groups to undergo induction of labour with either oxytocin or prostaglandin E2 vaginal pessary. Main outcome measures were induction-initiaton of labour interval, induction-delivery interval, maternal complications during induction, mode of delivery, fetal outcome and total hospital stay.

Results:  The induction-initiation of labour interval (P=0.005), duration of improvement in Bishop score, induction-delivery interval (P=0.011) and total hospital stay (P=0.018) were shorter in PGE2 induced patients. Moreover, majority of the patients delivered vaginally, had no maternal complications, did not require augmentation of labour, had less evidence of fetal distress (P=0.011) and better APGAR score at birth in this group. Majority of the neonates in the 2 groups did not require admission in neonatology unit (P=0.666).

Conclusion:  Prostaglandin E2 vaginal pessaries are very safe and effective to stimulate labour with ruptured membranes and poor Bishop score.

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How to Cite

Amjad, N., Rasheed, F., & Imran, T. (2010). Comparison of the Response of Oxytocin Versus Prostaglandin E2 Vaginal Pessary for Labour Induction in Prelabour Rupture of Membranes. Annals of King Edward Medical University, 15(2), 80. https://doi.org/10.21649/akemu.v15i2.36

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