Feto-Maternal Outcome in HEV Infection

Abstract

Objective:  To observe feto-maternal outcome in HEV +ve patients.

Study Design:  Observational Study.

Place and Duration of Study:  Sir Ganga Ram Hos-pital, Lahore from May 2008 to May 2010.

Patients and Methods:  This study included all preg-nant in whom HEV IgM / IgG diagnosed and presen-ted with raised bilirubin (> 2g/dl). Their course of ill-ness and fetal outcome was measured.

Results:  Out of 33 patients, 54% were less than 25 years and 31% (10/33) were upto 30 years. 15% (5/33) were above 30 years. Parity showed (36.63) ratio bet-ween primigravida and multigravida. 7/33 were less than 28 weeks gestation in whom only maternal out-come was studies and rest 26/33 were 28 and more weeks pregnant. Out of 26 patients, 5 babies were found dead in utero and 5 babies expired later on. (38% perinatal mortality). Perinatal morbidity in term of RDS, ANN and jaundice was found in 76% (16/26) babies. A total of 10/33 patients developed worsening of conditions with 6 having DIC, 2 with post partum hemorrhage and 2 with fulminant hepatic failure who expired and 6% mortality in mothers was observed and they were in last trimester.

Conclusion:  HEV infection during pregnancy is a high risk condition for both mother and baby.

Key Words:  HEV (Hepatitis E virus) ANN (asphy-sxia neonatorum) RDS (Resp Distress syndrome).