Perioperative Use of Low Dose Dopamine Protects Against Renal Injury in Patients Undergoing on-Pump Coronary Artery Bypass Surgery
Objectives: To compare and determine the effects of low dose dopamine in prevention of renal injury during cardiopulmonary bypass in patients undergoing isolated coronary artery bypass graft surgery.
Methods: Group I (n=25 patients) had mannitol 1g/Kg in the priming circuit and low dose dopamine (2ug/Kg/min) was administered in perioperative period starting at induction of anesthesia and continued till postoperative day 3. Group-II (n=25 patients) also had mannitol 1g/Kg in the priming circuit but dopamine was not administered in the perioperative period. The groups were matched in terms of patient characteristics and preoperative creatinine levels. Highest postoperative creatinine level within 5 days was taken as marker of renal injury. Student's t-test was used to assess the significance of differences in creatinine levels in two groups.
Results: There was a marginal increase in the postoperative creatinine level in group II patients, however this increase was statistically significant (p= 0.016).
Conclusion: We conclude that low dose of dopamine during perioperative period in patients undergoing coronary artery bypass surgery on cardiopulmonary bypass has a contributing factor in renal preservation.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments email@example.com