Mean Blood Ammonia Level After Treatment With Rifaximin Versus Neomycin In Chronic Liver Disease Patients Presenting With Hepatic Encephalopathy

  • Sami Ullah Mumtaz
  • Somia Iqtadar
  • Zafar Niaz
  • Tayyeba Komal
  • Sajid Abaidullah
Keywords: Chronic Liver Disease, Hepatic Encephalopathy, Rifaximin, Neomycin, Mean Blood Ammonia Level.

Abstract

Abstract |
Objective: To compare Rifaximin versus neomycin in chronic liver disease (CLD) patients presenting with hepatic Encephalopathy.
Methodology: This Randomized controlled trial was conducted at North Medical Ward, King Edward Medical University/ Mayo Hospital Lahore from June to December 2013. Total 100 patients of CLD with Hepatic Encephalopathy were included through non-probability, purposive sampling and were named group A & B by random division. In Group A, patients received conventional Antibiotic Neomycin 3000mg 6- hourly daily while in Group B; patients received Rifaximin 600mg 12-hourly daily orally for 21 days. Blood Ammonia levels of both groups after 21 days treatment were analyzed by the software SPSS version 16.
Results: The mean age of patients was 54.23±13.70 years with54 (54%) male and 46 (46%) females. Out of 54 male patients, 28 (52%) were randomized to Rifaximin and 26 (48%) were randomized to Neomycin. Similarly, out of 46 female patients, 22 (48%) were randomized to Rifaximin and 24 (52%) were randomized to Neomycin. The serum Ammonia level after treatment with Rifaximin was 58.00 (14-117) g/dl whereas with Neomycin was 87.00(38-381) g/dl. Significant difference was found between both groups (pvalue< 0.0001).
Conclusion: Rifaximin is a better treatment option in CLD patients with Hepatic Encephalopathy as compared to conventional Neomycin.

Published
2019-03-31
How to Cite
Mumtaz, S., Iqtadar, S., Niaz, Z., Komal, T., & Abaidullah, S. (2019). Mean Blood Ammonia Level After Treatment With Rifaximin Versus Neomycin In Chronic Liver Disease Patients Presenting With Hepatic Encephalopathy. Annals of King Edward Medical University, 25(1). Retrieved from https://www.annalskemu.org/journal/index.php/annals/article/view/2751
Section
Articles

Most read articles by the same author(s)