Membrane Handling of Calcium in Essential hypertension

Membrane Handling of Calcium in Essential hypertension

Authors

  • N SHORE
  • F MUNAWAR
  • S J KHAN

DOI:

https://doi.org/10.21649/akemu.v6i3.2131

Keywords:

Cytosolic Ca , altered calcium metabolism, essential hypertension.

Abstract

The relationship between cytosolic free Ca++ and increase in blood pressure may hold the key to unravel the causes and origin of essential hypertension. In 20, essential hypertensive patients and 25 normotensive controls, total serum calcium, serum ionized calcium and free erythrocyte intracellular Ca++, were measured. For calcium loading, lonophore A23187 was used. Intracellular Ca++ was measured by ion selective electrodes, which showed a highly significant increase in hypertensive patients as compared to normotensive controls. [1.00±0.11 versus 0.72±0.O6mmol/L]. While total serum calcium showed no significant difference, serum ionized Ca++ was significantly decreased in hypertensives as compared to controls. [1.028±0.11 versus 1.22±0.13mmol/L].The present results confirm an association between elevated erythrocyte Ca++ and essential hypertension. If generalized, the defect could lead to raised intracellular Ca++ in smooth muscle causing increased vascular tone and arterial hypertension.

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Published

01/16/2018

How to Cite

SHORE, N., MUNAWAR, F., & KHAN, S. J. (2018). Membrane Handling of Calcium in Essential hypertension. Annals of King Edward Medical University, 6(3). https://doi.org/10.21649/akemu.v6i3.2131

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