Re-evaluation of the Effects of NSAIDS on Blood Vessels
Background: Blood vessels regulate peripheral resistance and hence blood pressure. Their tone is controlled by autonomic nervous system, calcium influx and regulation of cycloxygenase-2 (COX-2). Autonomic nervous system also regulates calcium influx in to the cells. Some of NSAIDs like salicylates block calcium influx across the cell membrane. We have tried to find out effects of diclofenac, piroxicam and celecoxib on isolated blood vessel and their role in hypertension.
Methods: We have found effects of diclofenac, piroxicam and celecoxib on the rat aortic ring with intact endothelium and spiral strip of rabbit portal vein. The isolated tissues were stimulated with 1 μM of norepinephrine. Diclofenac 15 and 20μM and piroxicam 15 μM produced significant relaxation in rat aortic ring while there was no significant effect of celecoxib. Diclofenac 10, 15 and 20 μM, piroxicam 5 μM, celecoxib 5, 10 and 20 μM produced significant vasorelaxant effects on rabbit portal vein.
Conclusions: It is concluded that only non specific COX inhibitors affect arteriolar tone while venous tone is also decreased significantly not only by nonspecific but also by COX-2 inhibitors.
Key Words: Blood vessels, NSAIDs, Endothelium, Hypertension
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