TY - JOUR AU - Hafeez, Salma AU - Tahir, Zarfishan AU - Nauman, Nusrat PY - 2015/08/03 Y2 - 2024/03/29 TI - ANTIBODY TITERS IN ANIMAL BITE VICTIMS AFTER POST EXPOSURE VACCINATION WITH INTRADER-MALLY ADMINISTERED PURIFIED VERO CELL RABIES VACCINE USING MODIFIED THAI RED CROSS REGIMEN JF - Annals of King Edward Medical University JA - Annals KEMU VL - 20 IS - 4 SE - Articles DO - 10.21649/akemu.v20i4.677 UR - https://www.annalskemu.org/journal/index.php/annals/article/view/677 SP - 296 AB - <p><strong>Abstract</strong></p> <p><strong>Objective:&nbsp;&nbsp;</strong>To determine the seroconversion follow-ing rabies vaccination by intradermal route in cases of animal bite attending Anti rabies center, Lahore for post exposure prophylaxis.</p> <p><strong>Study Design:&nbsp; </strong>Cross sectional descriptive study.</p> <p><strong>Place and Duration:&nbsp;&nbsp;</strong>Antirabies center, Birdwood road Lahore, Microbiology laboratory, office of Bac-teriologist, Government of Punjab, Lahore.<strong></strong></p> <p><strong>Patients and Methods:&nbsp;&nbsp;</strong>Victims of all ages and both sexes having exposure with suspected rabid animal within 24 - 72 hours were included, fulfilling inclus-ion and exclusion criteria, over 3 months period from February to April 2011. Patients of Category II and III wounds were included. Purified vero cell vaccine (PVRV) with antigenic content &gt; 2.5 ml was used for</p> <p>Hafeez S.<sup>1</sup></p> <p>Assistant Professor Pathology</p> <p>Services Institute of Medical Sciences, Lahore</p> <p>Tahir Z.<sup>2</sup></p> <p>Professor of Microbiology</p> <p>Institute of Public Health, Lahore</p> <p>Nauman N.<sup>3</sup></p> <p>A.P.W.M.O.</p> <p>Anti Rabies Centre, Institute of Public Health, Lahore</p> <p>intradermal vaccination according to modified Thai Red Cross regimen (2-2-2-0-2). Each victim received 0.1 ml intradermal dose on each deltoid on day 0, 3, 7 and 28<sup>th</sup> day of bite. Blood samples from victims were taken on day 0, 14 and 35. Antibody titers were esti-mated by ELISA kit.</p> <p><strong>Results:&nbsp;&nbsp;</strong>Fifty cases were studied including 20 chil-dren. Male female ratio was 4:1. Optimum serocon-version (&gt; 0.5 IU/ml) was achieved in all cases by day 14. Antibody levels increased further (&gt; 4 IU/ml) in 92% cases on day 35. Geometric mean titers were 3.2 IU/ml and 6.2 IU/ml on day 14 and 35 respectively.</p> <p><strong>Conclusion:&nbsp;&nbsp;</strong>Intradermal route for cell culture &nbsp;rabies vaccine for postexposure prophylaxis in animal bite victims was efficacious and safe. The smaller dosage of vaccine was economically affordable by patients in referral centers.</p> <p><strong>Key words:&nbsp;&nbsp;</strong>Rabies, intradermal vaccine, Thai Red Cross regime, Purified vero cell vaccine.</p> ER -