TY - JOUR AU - Shahid, Adeela AU - Saeed, Muhammad Shahid AU - Shoaib, Muhammad PY - 2017/12/05 Y2 - 2024/03/28 TI - Glucose Intolerance, Insulin Resistance and Obesity Risk in Children with Family History of Type II Diabetes JF - Annals of King Edward Medical University JA - Annals KEMU VL - 23 IS - 3 SE - Articles DO - 10.21649/akemu.v23i3.2025 UR - https://www.annalskemu.org/journal/index.php/annals/article/view/2025 SP - AB - <p>Background: Genetic milieu increases the risk of diabetes; it results in disturbance of a number of&nbsp;metabolic pathways involved in blood glucose levels regulation and body weight. Family history of type&nbsp;II diabetes is one of the potential risk factors for developing diabetes.<br>Objective: The objective of the research was to determine early disturbance in the carbohydrate&nbsp;metabolism and the risk of overweight and obesity among children with family history of type II diabetes.<br>Materials and Methods: A total of 184 subjects (males &amp; females) with and without family history of&nbsp;diabetes (FHD) were included in the study. Body weight, height and waist circumference was measured,&nbsp;BMI was calculated. Fasting blood glucose (FBG), 2hr oral glucose tolerance test (2hr OGTT), HbA1C&nbsp;and serum insulin levels were determined in duplicate, and HOMA-IR was calculated for insulin&nbsp;resistance index. Results: It was observed that children of type II diabetic parents had significantly higher&nbsp;body weight, BMI, waist circumference, FBG, HbA1C, 2hr OGTT and HOMA-IR. There was high&nbsp;degree of prevalence of overweight, obesity, impaired fasting glucose (IFG) and impaired 2hr oral&nbsp;glucose tolerance test in subjects with FHD compared to those with no FHD. There was significant&nbsp;association of HbA1-C, IFG, impaired 2hr-OGTT and BMI with FHD. There was no association of FBG&nbsp;with BMI.<br>Conclusion: Children of type 2 diabetic parents have metabolic disturbances at an early age resulting in&nbsp;glucose intolerance and insulin resistance which predisposes them at a risk of type II diabetes and obesity.*There is no conflict of interest between authors.</p> ER -