TY - JOUR PY - 2017/12/05 Y2 - 2024/03/28 TI - Correlation of Urinary Neutrophil Gelatinase Associated Lipocalin with Routine Biomarkers used to Detect Kidney Injury in Systemic Lupus Erythematosus Patients with and without Nephritis JF - Annals of King Edward Medical University JA - Annals KEMU VL - 23 IS - 3 SE - Articles DO - 10.21649/akemu.v23i3.2012 UR - https://www.annalskemu.org/journal/index.php/annals/article/view/2012 SP - AB - <p>Systemic lupus erythematosus is associated with various complications with kidney involvement Lupus&nbsp;Nephritis(LN) being the most common. The routine biomarkers for the diagnosis of Lupus Nephritis&nbsp;have low specificity and sensitivity leading to delayed diagnosis of the condition thus increasing the rate<br>of mortality and morbidity. Hence there is need of a new biomarker showing correlation with the old&nbsp;biomarkers indicating the severity of renal damage. This search for a new marker to detect kidney&nbsp;involvement in patients with lupus induced nephritis can help to diagnose patients with kidney&nbsp;involvement at an early stage leading to timely initiation of therapy and decrease the rate of mortality and&nbsp;morbidity in these patients.<br>Objective: This study was designed to find out correlation of Neutrophil gelatinase associated lipocalin&nbsp;(uNGAL) with the biomarkers routinely used to measure kidney injury in patients with SLE and&nbsp;therefore finding the efficacy of NGAL in detection of renal involvement in these patients.<br>Methods: It is a cross sectional study conducted in Deptt. of Biochemistry and Chemical Pathology,&nbsp;Sheikh Zayed Hospital Lahore from June 2015 to June 2016 Eighty Four (n=84) SLE patients were&nbsp;selected for this study from Sheikh Zayed Hospital Lahore. These cases were divided into two equal&nbsp;groups (n=42) A and B. Group A comprised of SLE cases without kidney involvement and group B had&nbsp;cases with biopsy proven lupus nephritis. Urinary NGAL, serum and urinary creatinine and microalbuminuria&nbsp;were measured in both groups. Correlation of NGAL with serum and urinary creatinine,&nbsp;albumin creatinine ratio and creatinine clearance was calculated using Pearson's correlation and scatter&nbsp;plots were drawn for both groups.<br>Results:This study revealed that uNGAL correlated positively with creatinine and ACR (albumin creatinine&nbsp;ratio) and correlated in a negative manner with Creatinine clearance of the patients. However, the&nbsp;new biomarker showed no correlation with creatinine measured in urine.<br>Conclusion: Our study indicated that the new bio-marker i.e. uNGAL had a significant correlation with renal disease activity of SLE patients and thus can be used to assess the status of renal involvement in&nbsp;lupus patients.</p> ER -