@article{Shahid_Saeed_Rana_Mahmood_2012, title={Family History of Diabetes and Parental Consanguinity: Important risk for Impaired Fasting Glucose}, volume={17}, url={https://www.annalskemu.org/journal/index.php/annals/article/view/550}, DOI={10.21649/akemu.v17i3.550}, abstractNote={<p><strong>Abstract</strong></p> <p><strong>Objective:  </strong>Offspring of type 2 diabetics have incre-ased risk of metabolic disturbances. The aim of the study was to access the potential effect of family his-tory of type 2 diabetes (FHD) and parental consangui-nity on fasting plasma glucose (FPG) levels.</p> <p><strong>Design:  </strong>Non diabetic offspring of one or both parents with type 2 diabetes and healthy controls of compar-able age, without a FHD were the subjects of this stu-dy. FHD was defined by the presence of type 2 diabe-tes in one or both parents of the subject. Consanguinity was defined as history of marriage with first cousin. FPG levels were determined in cases and controls.</p><p><strong>Results:  </strong>IFG was identified in 42% subjects with a FHD and in 14% without FHD. We found a strong in-dependent association of FHD with impaired fasting glucose in both males and females by logistic regres-sion analysis after adjusting the data for age sex and BMI. Parental consanguinity modifies the effect of FHD on IFG.</p><p><strong>Conclusion:</strong>  We concluded that family history of dia-betes and parental history of consanguinity determine the risk for impaired fasting glucose in our population.</p><p><strong>Keywords:<em>  </em></strong>Impaired fasting glucose; Parental con-sanguinity; Family history of diabetes.</p>}, number={3}, journal={Annals of King Edward Medical University}, author={Shahid, Adeela and Saeed, Shahid and Rana, Sobia and Mahmood, Saqib}, year={2012}, month={Feb.}, pages={280} }