@article{Ahmed_Yasir_Naeem_Amin_2013, title={Efficacy of 17 Αlpha Hydroxy Progesterone in Prevention of Preterm Labour in High Risk Patients}, volume={18}, url={https://www.annalskemu.org/journal/index.php/annals/article/view/394}, DOI={10.21649/akemu.v18i2.394}, abstractNote={<p class="MsoNormal" style="margin-bottom: 0.7pt; text-align: justify;"><strong><span style="font-family: 'Times New Roman', serif;">Objective:</span></strong><span style="font-family: 'Times New Roman', serif;">  To determine the efficacy of 17 α OH progesterone in prevention of preterm labour in high risk patients.<strong></strong></span></p> <p class="MsoNormal" style="margin-bottom: 0.7pt; text-align: justify;"><strong><span style="font-family: 'Times New Roman', serif;">Study Design:  </span></strong><span style="font-family: 'Times New Roman', serif;">Randomized control trial.<strong></strong></span></p> <p class="MsoNormal" style="margin-bottom: 0.7pt; text-align: justify;"><strong><span style="font-family: 'Times New Roman', serif;">Place and Duration of Study:</span></strong><span style="font-family: 'Times New Roman', serif;">  Department of Obs-tetric and gynecology, Fatima Memorial Hospital, Lahore during January 2008 to December 2010.</span></p> <strong><span style="font-size: 11pt; line-height: 115%; font-family: 'Times New Roman', serif;">Patients and Methods:</span></strong><span style="font-size: 11pt; line-height: 115%; font-family: 'Times New Roman', serif;">  Two hundreds women fulfill-ing inclusion criteria were recruited in study and were divided into two groups (treated and non-treated). The 17 α OH progesterone injections were started from 20 weeks and on ward on weekly basis until 36 weeks of gestation or delivery whichever occurred first. The pri-mary end point was preterm birth, defined as birth occurring before 37 weeks of gestation. Other out</span><span style="font-family: 'Times New Roman', serif; text-align: justify;">comes were frequency of episodes of uterine contrac-tions, episodes of preterm labour and response to treat-ment with beta – mimetics.</span><p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify;"><strong><span style="font-family: 'Times New Roman', serif;">Results:</span></strong><span style="font-family: 'Times New Roman', serif;">  The treatment with 17 α OH progesterone helped to prolong pregnancy to full term in 66% as compared to those non treated 11%. There was 4.17 (2.65 – 6.60) time higher RR in non-treated group as compared to treated group for preterm delivery bet-ween 35 – 37 weeks. Similarly the RR was 4.94 (2.61-8.58) and 6.33 (2.95 – 13.60) in non-treated group as compare to treated group of preterm deliveries bet-ween 32 – 35 weeks and < 32 weeks respectively.<strong></strong></span></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify;"><strong><span style="font-family: 'Times New Roman', serif;">Conclusion:</span></strong><span style="font-family: 'Times New Roman', serif;">  Women with previous preterm births when treated with 17 α OH progesterone showed sig-nificant reduction in spontaneous early preterm deli-very.<strong></strong></span></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify;"><strong><span style="font-family: 'Times New Roman', serif;">Keywords:</span></strong><span style="font-family: 'Times New Roman', serif;">  17 α OH progesterone, preterm delivery, previous preterm deliveries.<strong></strong></span></p> <p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify;"><span style="font-family: 'Times New Roman', serif;"> </span></p>}, number={2}, journal={Annals of King Edward Medical University}, author={Ahmed, Farhatulain and Yasir, Shamila and Naeem, Noor-i-kiran and Amin, Attiqa}, year={2013}, month={May}, pages={158} }