@article{Aman_Nadeem_2010, title={Comparison of the Efficacy and Safety of Topical 5% Minoxidil Solution Alone and in Combination with 0.05% Betamethasone Dipropionate Cream in the Treatment of Alopecia Areata}, volume={16}, url={https://www.annalskemu.org/journal/index.php/annals/article/view/170}, DOI={10.21649/akemu.v16i1 SI.170}, abstractNote={<p><strong>Background:  </strong>Alopecia Areata (AA) is a fairly common skin problem, accounting for approximately 2% of new derma-tological outpatients worldwide. There is a dire need for an innovative approach in the treatment of this disorder.<strong></strong></p> <p><strong>Objective:  </strong>Our objective was to assess the efficacy and safety of topical 5% minoxidil solution alone and in combination with 0.05% betamethasone dipropionate cream in the treatment of alopecia areata.<strong></strong></p> <p><strong>Method:  </strong>Fifty patients with alopecia areata, ages ranging from 18 to 55 years, were enrolled in the study. They were ran-domly divided into two groups, each having 25 patients. The patients in group A, were advised to apply 5% minoxidil solu-tion, twice daily for a period of three months. Whereas the patients of group B, were advised to apply 5% minoxidil solution followed by, 30-60 minutes later, the application of 0.05% betamethasone dipropionate cream. Patients of both groups applied the medicines for a period of three months after which they were followed up for the next three months. The efficacy of the drugs was assessed on the basis of percentage re-growth of hair as: Excellent (> 90%), Good (70 - 90%), Satisfactory (50-69%) and Poor (< 50%). The safety of treatment administered was assessed on the basis of local or systemic side effects of the drugs.<strong></strong></p> <p><strong>Results:  </strong>Out of 50 evaluable patients, there were 39 males and 11 females. Minoxidil 5% alone showed an excellent result in 3 (12%) patients, a good response in 10 (40%) and poor in 12 (48%) patients. Minoxidil 5% plus Betamethasone diapro-pionate cream revealed an excellent response in 11 (44%) patients, good in 9 (36%) and poor in 5 (20%) cases. Comparison of hair re-growth count in the bald patches over a 24 weeks period, showed both treatments to be effective. The combination therapy, however, seemed to be more effective in the re-growth of hair at week 12 and 24. Both treatments were well tole-rated.</p> <p><strong>Conclusions:  </strong>Both treatments are effective and safe over a 12 weeks period. However, the combination therapy is more effective than minoxidil solution alone in the treatment of alopecia areata.</p> <p><strong>Key Words: </strong> Alopecia areata, minoxidil solution, betamethasone dipropionate.</p>}, number={1 SI}, journal={Annals of King Edward Medical University}, author={Aman, Shahbaz and Nadeem, Muhammad}, year={2010}, month={Jul.} }