Long Term Follow up of Multi Drug Resistance Tuberculosis Patients After 3-4 Years of Starting Second Line Anti Tubercular Drugs

  • Sana Rehman
  • Muhammad Kashif Munir
  • Rizwan Iqbal
  • Muhammad Saqib Saeed
  • Muhammad Aasim
Keywords: Follow-up, MDR-TB, Second line drugs, pulmonary TB.


Objective: To determine the rates of mortality, default, relapse and treatment success in MDR TB patients during the last few years and to observe other risk factors associated with this disease.Methods: This cohort study was conducted during April 2014 to November 2015. Confirmed MDR TB patients who started their antitubercular treatment during years 2008 to 2010were included in this study. Addresses and contact numbers of all the patients were noted from the files. Patients who died during orafter treatment due to any reason, an International standard verbal autopsy questionnaire was filled on.Results: Data of 131 patients who started their antitubercular treatment during year 2008 to 2010 was collected retrospectively and 31 (23.6%) were excluded from the study. Off the remaining 100 patients 71 were male and 29 were females. Thirty five out of 100 patients died during or after completion of antituberculartreatment while 65% were alive. Records shown that 62% of the patients have family history of TB, furthermore 71% of the total patients had previous history of anti-tubercular treatment. Of 35 death cases 65% had previous history of antitubercular treatment. About 55.4% of the alive patients had good compliance while 59.0% of the death cases had bad or no compliance.Conclusions: High mortality rate of patients after long time from initiation of MDR TB treatment was observed in present study revealed associated risk of death during or after completion of treatment.