Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy

  • Muhammad Khalid Ch
  • Muhammad Saqib Saeed
  • Rizwan Iqbal
  • Akhtar Ali

Abstract

AbstractBackground:  Tuberculous pleurisy is a common extrapulmonary manifestation and is second to tuberculous lymphadenitis. Due to its paucibacillary in origin, its diagnosis is a challenge. Furthermore, it is also complicated by the emergence of MDR. Gene Xpert MTB/RIF is a new rapid promising innovation for the detection of mycobacterium tuberculosis and its resistance to Rifampicin, giving result within two hours.Objective:  To evaluate the diagnostic role of Gene Xpert MTB/RIF in suspected cases of tuberculous pleurisy.Study Design:  Cross sectional study.Study Setting:  Institute of Chest Medicine Mayo Hospital – a Tertiary Care Hospital affiliated with King Edward Medical University, Lahore.Methodology:  The study group, one hundred (M-60 and F-40) cases having exudative, predominantly lymphocytic pleural effusion with strong suspicion of tuberculous in origin were enrolled randomly for Gene Xpert MTB / RIF.Results:  Among one hundred study cases, Gene Xpert detected mycobacterium tuberculosis in 12(12%) cases [M-8 (13.3%) and F-4 (10%)]. Resistance to Rifampacin was detected in 6 (6%) cases [M-2 (3.3%) and F-4 (10%)].Conclusion:  Gene Xpert MTB/RIF is a useful new rapid promising technique to diagnose tuberculous pleurisy. Although at present it has limited availability and utility.Key Words:  Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.
Published
2016-02-13
How to Cite
CH, Muhammad Khalid et al. Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy. Annals of King Edward Medical University, [S.l.], v. 22, n. 1, p. 78, feb. 2016. ISSN 2079-0694. Available at: <http://www.annalskemu.org/journal/index.php/annals/article/view/803>. Date accessed: 27 apr. 2018. doi: https://doi.org/10.21649/akemu.v22i1.803.
Section
Medicine & Allied

Keywords

Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.