COMPARISON BETWEEN NIFEDIPINE AND RITODRINE AS AN EFFECTIVE TOCOLYTIC AGENT FOR PRETERM LABOUR
AbstractAbstract Background: Preterm labour is not uncommon and its incidence is 10% of all the pregnancies. It can be a cause of maternal and fetal morbidity and mortality. Of many available tocolytic agents, ritodrine is fre-quently used but it can leads to maternal and fetal complications which include tachycardia or hypertens-ion. Nifedipine is considered to avoid from these com-plications. However, its efficacy is still under debates. Objectives: The objective of the study was to com-pare the efficacy of nifedipine with ritodrine in tocoly-sis of preterm labor. Study Design: It was a randomized controlled trial. Place and Duration of Study: This study was condu- Shahzad N.1 Assistant Professor Department of Obstetrics & Gynaecology, KEMU / Lady Willingdon Hospital, Lahore Saleem F.2 Assistant Professor Department of Obstetrics & Gynaecology, KEMU / Lady Willingdon Hospital, Lahore Shahid M.3 Associate Professor Dept of Paediatrics SIMS / Services Hospital, Lahore Malik A.4 Professor of Obstetrics & Gynaecology KEMU / Lady Willingdon Hospital, Lahore cted at unit 111 Lady Willingdon Hospital Lahore and duration was one year from 1.1.2014 to 31.12.2014. Methodology: One hundred and twenty patients were randomly divided in two equal groups. Group A pati-ents were given nifedipine and in group B received ri-todrine for prolongation of labor. The two groups were compared with each other for efficacy. Data was colle-cted on a specially designed Performa. Results: The efficacy of nifedipine was 71.1% and ritodrine was 31.1%. The results were statically signi-ficant (p-value < 0.05). Conclusions: Nifedipine was proved to be more effe-ctive than ritodrine and the results were statistically significant Key Words: Preterm labor; ritodrine; nifedipine; pro-longation of labor.
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