Clinical Spectrum of Early Onset Neonatal Sepsis

  • Muhammad Khalid Masood
  • Naeem Butt
  • Saadia Sharif
  • Yaqoob Kazi


Objective:  To describe clinical spectrum of early onset neonatal sepsis in our set up. Materials and Methods:  This study was conducted at Neonatology Unit, Department of Pediatric Medi-cine, Services Hospital, Lahore from 01-07-2007 to 31-12-07. Subjects and Methods:  The data of all the admitted neonates with culture proven early onset neonatal sep-sis were analyzed for age, weight, gender, and clinical presentations at the time of admission. Results:  The mean age of neonates at time of presen-tation was 2.26 ± 1.661 days. Fifty seven percent were boys with male to female ratio 1.32 : 1.The mean weight at time of presentation was 2.9 kilograms, maximum with the standard deviation of 0.319. Ref-usal to feed was the most common 68%, followed by respiratory distress 47%, and lethargy 41%. Other symptoms included fits 20%, vomiting 18%, irrit-ability 16%, diarrhea 14%, jaundice 8%, bleeding 8% and fever in 7% of patients. Temperature instability (51%) was the most common clinical sign followed by poor sucking 48%, shock 25%, tachycardia 16%, cya- nosis 12%, bradycardia 9%, petechiae and purpura 12%, grunting 5%, apnea 5%, and abdominal disten-sion in 2% of patients. Conclusion:  Early onset neonatal sepsis has non specific signs and symptoms so high index of suspi-cion should be kept in mind while managing a sick neonate so that early and prompt treatment can be instituted.
How to Cite
MASOOD, Muhammad Khalid et al. Clinical Spectrum of Early Onset Neonatal Sepsis. Annals of King Edward Medical University, [S.l.], v. 17, n. 1, p. 27, sep. 2011. ISSN 2079-0694. Available at: <>. Date accessed: 25 nov. 2017. doi: