Urinary Tract Infections- Experience with Lomefloxacin

Abstract

A randomised study was conducted to see the efficacy and safety of Lomefloxacin in the treatment of complicated urinary tract infections. A total of 30 patients were included in the study. Males were 14 (46.7%), while females were 16 (53.3%).Their mean age was 39.6 years (range 18-65 years). Chronic renal failure of unknown etiology was present in 7, diabetic nephropathy in 7, chronic glomerulonephritis in 5, chronic pyelonephritis in 3, obstructive nephropathy due to stones in 2, and 2 cases were post renal transplant. 2 patients had Lupus nephritis, whereas there were two patients with hereditary nephritis. E. coli was the most frequently isolated organism, (43.3%), followed by Proteus (23.3%), Staph aureus (13.3%) Klebsiella (10%). Streptococcus faecalis, Pseudomonas and Acenitobacter were isolated in 3.3% each. At the end of the treatment, 19 patients (63.3%) had complete cure, clinical improvement occurred in 10 patients (33%). There was failure to relieve symptoms in 1 patient (3.3%). The drug was well tolerated and found to be effective in the management of complicated urinary tract infection.