Effect of Subclinical Hypothyroidism on Fasting Serum Low Density Lipoprotein-C and High Density Lipoprotein-C

  • Syed Mohammad Zubair King Edward Medical University
  • Farhat Ijaz
  • Rana Khurram Aftab

Abstract

AbstractNumerous effects on metabolism of Lipids, its absorption, amalgamation, and control is under the influence of Thyroid Hormone. The scientists at international are exploring the possibility of establishing a link between subclinical hypothyroidism and lipids. We conducted this research to test the hypothesis that TSH, and levels of LDL-C and HDL-C are significantly associated in subjects with SCH.Methods:  This cross sectional study was conducted at Physiology Department, KEMU in collaboration with Centre for Nuclear Medicine (CENUM), Mayo Hospital & KEMU, Lahore. Simple Random sampling technique was employed to collect the sample. A total of 100 cases were selected (50 with SCH and 50 with Thyroid Profile within normal range as control) Levels of TSH, LDL-C and HDL-C were measured in fasting serum samples.Results:  TSH levels in subclinical hypothyroidism SCH were 8.69 mlU/L and Euthyroid showed to be1.39 mlU/L. Mean HDL levels were 39.74 mg/dL in Subclinical Hypothyroidism subjects and 43.48mg/dL in euthyroid. The LDL-C pattern was in SCH 182.82 mg/dL and Euthyroids 161.24 mg/dL.Conclusion:  The Subclinical hypothyroidism has statistically significant effect in lowering HDL-C and increasing LDL-C level.AbstractNumerous effects on metabolism of Lipids, its absorption, amalgamation, and control is under the influence of Thyroid Hormone. The scientists at international are exploring the possibility of establishing a link between subclinical hypothyroidism and lipids. We conducted this research to test the hypothesis that TSH, and levels of LDL-C and HDL-C are significantly associated in subjects with SCH.Methods:  This cross sectional study was conducted at Physiology Department, KEMU in collaboration with Centre for Nuclear Medicine (CENUM), Mayo Hospital & KEMU, Lahore. Simple Random sampling technique was employed to collect the sample. A total of 100 cases were selected (50 with SCH and 50 with Thyroid Profile within normal range as control) Levels of TSH, LDL-C and HDL-C were measured in fasting serum samples.Results:  TSH levels in subclinical hypothyroidism SCH were 8.69 mlU/L and Euthyroid showed to be1.39 mlU/L. Mean HDL levels were 39.74 mg/dL in Subclinical Hypothyroidism subjects and 43.48mg/dL in euthyroid. The LDL-C pattern was in SCH 182.82 mg/dL and Euthyroids 161.24 mg/dL.Conclusion:  The Subclinical hypothyroidism has statistically significant effect in lowering HDL-C and increasing LDL-C levels.Key words:  Subclinical hypothyroidism, TSH, HDL-C, LDL-C

References

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Published
2017-06-09
How to Cite
ZUBAIR, Syed Mohammad; IJAZ, Farhat; AFTAB, Rana Khurram. Effect of Subclinical Hypothyroidism on Fasting Serum Low Density Lipoprotein-C and High Density Lipoprotein-C. Annals of King Edward Medical University, [S.l.], v. 23, n. 2, june 2017. ISSN 2079-0694. Available at: <http://www.annalskemu.org/journal/index.php/annals/article/view/1569>. Date accessed: 25 nov. 2017. doi: https://doi.org/10.21649/akemu.v23i2.1569.
Section
Articles

Keywords

Subclinical hypothyroidism, TSH, HDL-C, LDL-C.