Clinical Profile of Type 1 Diabetes Mellitus in Saudi Children: a Hospital Based Study

Muhammad Rafique, Fouzia Ishaq, Muhammad Khalid Masood, Youssef Ali Mohamad Al-Qahtani, Walaa Ibrahim Ahmed Assiri, Manal Ahmed Ali Assiri, Muhammad Atif Qureshi, Shumaila Zia

Abstract


Abstract

Objective:  To determine the clinical characteristics of newly diagnosed type 1 diabetes mellitus (T1DM) in children under15 years of age. Cross sectional study conducted at Aseer Central Hospital Abha, South-western Saudi Arabia from June 2011 – May 2015.

Patients and Methods:  Study included 141 Saudi children, < 15 years old with newly diagnosed T1DM. The demographic and laboratory data were collected from file records. The patients were divided into younger (< 5 yr), middle (5 – 10 yr) and older (>10 – 15 yr) age groups. Data were analyzed by using SPSS version 16.

Results:  Age of 141 children at onset of T1DM (mean ± SD) was 6.5 ± 3.2 years and majority 62 (44%) belonged to middle age group. Older 43 (30.5%) age group had female predominance (2:1) (p < 0.0001). Diabetic ketoacidosis (DKA) (39%), obesity (11%) and male predominance (2.6:1) were found in younger 36 (25.5%) age group (p < 0.0001). Family history (F/Hx) of T1DM 29 (20.6%) and HbA1c (10.36 ± 1.8%) successively increased with advancing age of patients. Main presenting symptoms like polyuria (96%), polydipsia (85%), weight loss (62%), nocturia (47%), polyphagia (28%) and DKA (22%),were significantly more frequent in children with F/Hx of T1DM (p < 0.0001). Duration of symptoms at first presentation was 17.3 ± 10.7 days and daily insulin requirement was found 0.82 ± 0.2 units/ Kg.

Conclusion:  Polyuria, polydipsia, weight loss, noctu-ria and polyphagia were the main presenting symptoms and more frequent in middle age group children especially having F/Hx of T1DM. Under five years, obese and male children were found at higher risk for DKA development. Girls usually present late in adolescent age.


Keywords


Type 1 diabetes mellitus, Saudi Arabia, diabetic ketoacidosis, children, symptoms.

Full Text:

PDF


DOI: http://dx.doi.org/10.21649/akemu.v22i4.1458

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

(C) Annals of KEMU, King Edward Medical University, Lahore, Pakistan.